In essence, urinary podocin:nephrin ratio of the DKD group was significantly higher than that of the HTN group (110.6 [IQR 34.9–328.4] vs. 17.6 [IQR 9.3–48.7], Mann Whitney U test, p = 0.0019), while there was no significant difference in urinary podocin:AQP2 ratio (1.40 [IQR 0.30–4.54] vs. 0.63 [IQR 0.13–2.63], p = 0.15) or nephrin:AQP2 ratio (0.012 [IQR 0.005–0.046] vs. 0.027 [IQR 0.007–0.062], p = 0.13) between the DKD and HTN groups. This evidence concerns the gene AQP2 and diabetic kidney disease.