Of note, PEDF is not only proved to prevent atherosclerosis by inhibiting thrombosis or inhibiting inflammatory reaction of vascular endothelial cells caused by oxidative stress in vivo and in vitro experiments [70, 71], but also proved to be significantly overexpressed in CAD patients in the population, which may act as a protective response and biomarker of CAD [72–74]. The gene discussed is SERPINF1; the disease is atherosclerosis.