CD4 and HIV infectious disease: However, the difference in MM level was significant only in HLA-DR–CD4+T cells, not in HLA-DR+CD4+T cells, in the context of HIV infection (HLA-DR-: UNT vs. HD P = 0.0041, ART vs. HD P = 0.0125, ART vs. UNT P = 0.3332; HLA-DR + UNT vs. HD P = 0.0438, ART vs. HD P = 0.4966, ART vs. UNT P = 0.0593 ).