AIM2 and infection: In the canonical pathway, pyroptosis is triggered by intracellular sensors such as NOD‐like receptor family pyrin domain containing 3 (NLRP3) and absent in melanoma 2 (AIM2), by which the cells can detect damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs), caused by pathogen infection, pathological injury, and some other stimuli (Sharma and de Alba 2021; Shi et al. 2017; Van Opdenbosch and Lamkanfi 2019).