During the malignant transformation, dysregulation of METTL3/ALKBH5 induced the up-regulation of m6A levels on SLC3A2/SLC7A5 mRNA in cells, which promoted translation and expression of SLC3A2/SLC7A5, and thus accelerated bladder cancer growth and metastasis. Here, ALKBH5 is linked to urinary bladder cancer.