Notably, the turquoise module exhibited the highest correlation with both CD8 + T cell infiltration and pN stage in CRC (R = -0.21, P = 4e-04; R = 0.19, P = 0.001, respectively) (Fig. 1A), suggesting genes in the turquoise module may be closely correlated with the malignancy and prognosis of CRC. Here, CD8A is linked to colorectal carcinoma.