Besides, myeloid-derived suppressor cells (MDSC) were also enriched in LOXL1 high expression group compared to LOXL1 low group, which usually expand during tumorigenesis and exert immunoinhibitory activity by suppressing anti-tumor CD8 + T cells (Jiang et al. 2020; Gabrilovich et al. 2012; Cui et al. 2013). Here, CD8A is linked to neoplasm.