By analyzing CRC samples from the TCGA cohort, we observed prominent enrichment in oncogenesis and metastasis-related pathways across all LOXL1 high expression samples, including EMT process, IL-6/JAK/STAT3 signaling, Hedgehog pathway, etc. Consistently, a wealth of data suggested that aberrant hyperactivation of the IL-6/JAK/STAT3 pathway could drive the metastasis of CRC cells while severely hindering the antitumor immune response in the TME (Wang and Sun 2014). This evidence concerns the gene LOXL1 and colorectal carcinoma.