By analyzing CRC samples from the TCGA cohort, we observed prominent enrichment in oncogenesis and metastasis-related pathways across all LOXL1 high expression samples, including EMT process, IL-6/JAK/STAT3 signaling, Hedgehog pathway, etc. Consistently, a wealth of data suggested that aberrant hyperactivation of the IL-6/JAK/STAT3 pathway could drive the metastasis of CRC cells while severely hindering the antitumor immune response in the TME (Wang and Sun 2014). The gene discussed is STAT3; the disease is colorectal carcinoma.