Both Col1a2G610c/+ and Crtap–/– mouse models recapitulated OI phenotypes due to excessive TGF-β signaling.236,237 Importantly, anti-TGF-β antibody 1D11 treatment both corrects the bone phenotype and improves fracture healing in the OI mouse model, highlighting the potential of targeting TGF-β signaling in treatment for OI.236,237. The gene discussed is TGFB1; the disease is osteogenesis imperfecta.