Recently, to enhance tumor tropism, we further engineered our sTGFβRIIFc expressing adenoviruses with a 9-amino acid-long tumor homing-cell penetrating peptide (LyP-1) into the HI loop of Ad5 adenoviral fiber to generate AdLyp.sT from Ad.sT, and mHAdLyp.sT from mHAd.sT [6]. Here, PTPN22 is linked to neoplasm.