No significant changes of TNF-α in both spleen and tumor was seen at any of our ending points (data not shown), but the localized stimulation of two critical Th1 cytokines (IL-12 and IFN-γ) in tumors by mHAdLyp.sT suggests that mHAdLyp.sT is able to help prime antitumor immunity directly in the tumor, specifically with IL-12, which was elevated by mHAdLyp.sT at both early and late stages of tumor resistance. This evidence concerns the gene TNF and neoplasm.