METTL3 and colorectal carcinoma: We overexpressed RanGAP1 in METTL3 and YTHDF1 knockdown CRC cells (DLD1 and HCT116) (Fig. 4J), demonstrating that the overexpression of RanGAP1 can partially rescue the tumorigenesis and metastasis functions affected by shMETTL3/YTHDF1 (Fig. 4K-N).