High2 expressed TGFB1, a key player in tumour invasion and metastasis15,16, ITGA10 a prognostic marker17 and therapeutic target18 for myxofibrosarcoma, and EZR a cell adhesion myosin regulating tumour proliferation and metastasis19 (Fig. 1c, d and Supplementary Fig. 2). The gene discussed is TGFB1; the disease is neoplasm.