NFKB1 and cancer: In particular, we focused on three co-expressed gene modules: Module 1 (cartilage development, green arrow in Fig. 3b) represented benign development trajectory of chondrocyte (Fig. 3c); Modules 3 and 8 (cancer development; red arrow in Fig. 3b) included genes that are associated with malignant transformation that involve early stress response including cellular response to ER stress (module 8) and later NF-κB pathway activation (module 3; Fig. 3c).