IGHG3 and dengue disease: Eighteen of the 31 individuals (58%) with ZIKV VLP-reactive IgG responses showed ZIKV VLP-binding IgG3 antibodies (Supplementary Fig. 7a) despite the similar total human IgG (P = 0.2024) and relative IgG3-specific antibodies (P = 0.1385) among the healthy controls and DF patients (Supplementary Fig. 7b).