We evaluated the cell viability using MTT assay, flow cytometry, and the expression of Bax, CASP-3, TP53INP1 and miRNA-221 by RT-qPCR, in order to elucidate the mechanism of TPGS mixed micelles formula and ferulic acid in Caco-2 human colorectal cancer cell line. This evidence concerns the gene TP53INP1 and colorectal cancer.