1,309 WHO Grade 2 and 3 glioma patients from AACR GENIE v13.0 datasets were grouped based on IDH1 mutation status, and individual cases were aligned based on CNVs status of EGFR, CDKN2A, and PTEN, as well as mutation status of TP53 and ATRX (Fig. 4B,C). The gene discussed is IDH1; the disease is central nervous system cancer.