OSBPL2 and colorectal carcinoma: Therefore, CRC cells were stained with F-actin, Paxillin, and Cortactin to directly visualize focal adhesions and invadopodia induced by Collagen I. Decreased OSBPL2 expression improved focal adhesion and invadopodia in HT29 and HCT116 cells (Fig. 3J–M).