Therefore, CRC cells were stained with F-actin, Paxillin, and Cortactin to directly visualize focal adhesions and invadopodia induced by Collagen I. Decreased OSBPL2 expression improved focal adhesion and invadopodia in HT29 and HCT116 cells (Fig. 3J–M). The gene discussed is PXN; the disease is colorectal carcinoma.