We found several significantly differentially over-abundant clusters, however, the most differentially abundant was a subset of CD14+/CCR2+/CD115+ classical monocytes (Supplementary Fig. 10a–c; T-statistic = 10.7, P = 1.34e-25, BH-corrected t test; Supplementary Datasets 3, 4)48 appearing uniformly over-abundant in T1D subjects (cluster-5,8; Fig. 3f, g; Supplementary Datasets 1–8)49–51. The gene discussed is CSF1R; the disease is type 1 diabetes mellitus.