We found that CCR7_DC-CD8+ T cell doublets were more frequent than other CCR7_DC-T cell combinations (Supplementary Fig. 7c, d), and PICs containing activated DC (CCR7+FSCN1+CD274+) highly co-expressed CD8B, PRF1, GZMB and PDCD1 (Fig. 4g), confirming that in NSCLC, CCR7+ DC and effector CD8+ T cells physically interact. The gene discussed is PRF1; the disease is non-small cell lung carcinoma.