PVR and neoplasm: Importantly, we identified several lymphocyte activation ligands32,35,36 that were significantly upregulated on Ccr7_DC.2 versus other tumour CCR7+ DC states and Kaede-red dLN CCR7+ DCs, such as Il12b, Tnfsf4, Tnfsf9, Cd70 and Pvr (Supplementary Fig. 6e).