CD274 and neoplasm: These included a major Prf1highGzmhighPdcd1+Havcr2+ cluster resembling “exhausted” T (TEX) cells and a Pdcd1+Tcf7+Slamf6+ cluster resembling “stem-like” T cells39,40 (Fig. 5a, Supplementary Fig. 8c, d), that were predominantly tumour-resident and expanded with anti-PD-L1 (Fig. 5b, Supplementary Fig. 8e).