Conditional deletion of HIF-1α expression in NK cells failed to significantly impair tumor growth (Fig. 4J) and while there was a modest increase in the number of NK cells in the tumor (Fig. 4K), no differences in the % of KR+ NK cells, the proportion of NK cell subsets, nor production of CCL5, IFNγ, granzyme A or granzyme C was detected (Fig. 4L–O). The gene discussed is HIF1A; the disease is neoplasm.