PAK5 and acute myeloid leukemia: For example, ProKinO mining using the SPARQL protocol and RDF query language (SPARQL) identified p21-activated protein kinase 5 (PAK5) as a frequently mutated dark kinase in human cancers, including a previously unrecognized role in acute myeloid leukemia.(p51) Furthermore, the impact of oncogenic mutations on PAK5 structure and function was predicted using the structural visualization tools built into the ProKinO browser.(p51) In another example, effective integration of informatics and experimental approaches resulted in the functional illumination of the understudied pseudokinase, PSKH2.