It has been reported that mammalian eIF2A is required for the translation of certain non-AUG initiated uORFs and that translation of these uORFs upregulates translation of the downstream CDS when eIF2α is phosphorylated during ER stress (Starck et al., 2016) or during tumor initiation (Sendoel et al., 2017). The gene discussed is EIF2A; the disease is neoplasm.