Crofelemer was also found to strongly inhibit the intestinal calcium-activated chloride channel TMEM16A, also known as ANO1 and DOG (anoctamin 1 and Discover On Gastrointestinal Stromal Tumors) by a voltage-independent inhibition mechanism, with a maximum inhibition of 90% and an IC50 of 6.5 μM [7]. This evidence concerns the gene ANO1 and gastrointestinal stromal tumor.