Top 10 pathways at 17 months of age included pathways related to collagen (e.g. GP6 signaling pathway and hepatic fibrosis hepatic stellate cell activation), growth signaling (IGF-1 signaling, molecular mechanisms of cancer) and the neuromuscular junction (synaptogenesis signaling pathway) (Fig. 4C). The gene discussed is GP6; the disease is Hepatic fibrosis.