FGFR2 and cholangiocarcinoma: In line with this, postzygotic somatic activating FGFR2 alterations were found in various cancer types including colon, breast, gastric, endometrial, esophageal and cholangiocarcinoma (Kunii et al. 2008; Zhang et al. 2009; Reintjes et al. 2013; Mathur et al. 2014; Kwak et al. 2015; Helsten et al. 2016; Smyth et al. 2017; Shi et al. 2018).