BACE1 and Alzheimer disease: BACE1 is primary enzyme accountable for the production of Aβ, which plays an important role in the pathogenesis of AD (Vassar et al. 1999; Cai et al. 2001; Selkoe 2012), and can bind to the long non-coding RNA (BACE1-AS) transcribed from its complementary strand to stabilize BACE1 mRNA (Faghihi et al. 2008).