PRKN and Parkinson disease: Consistent with this, it was found that Lewy bodies in the SN of early PD brains may be associated with p62 (Kuusisto et al. 2003), both in terms of oxidative damage shown by the p62 gene promoter in the frontal cortex of PD brains and in terms of p62 proteasomal degradation (Du et al. 2009) due to mutations in the parkin gene that stabilizes p62 in PD (Lesage and Brice 2009; Song et al. 2016).