BACE1 and Alzheimer disease: Nrf2 inducers, such as sulforaphane from cruciferous vegetables, and tert-butylhydroquinone (tBHQ) (Kraft et al. 2004), activate Nrf2 to inhibit the expression of BACE1 and BACE1-AS through the modification of the cysteine residue of Keap1 to prevent the production of Aβ, a key pathogenic process in the early stages of AD (Dinkova-Kostova et al. 2002; Kobayashi and Yamamoto 2006; Bahn et al. 2019).