Among them, Numerous areas of the brain and different types of brain cells express NOX2, including neurons in striatum (McCann et al. 2008; Guemez-Gamboa et al. 2011) and SN (Zawada et al. 2011; Qin et al. 2013), and compared with neurons and astrocytes, it has a higher expression in microglia More expressed, which was also confirmed in experimental models of PD and PD (Gao et al. 2002; Zhang et al. 2005b; Wu et al. 2005). This evidence concerns the gene CYBB and Parkinson disease.