Interestingly, some cancer cell lines did not undergo ferroptosis in the presence of GPX4 inactivation, suggesting the existence of other anti-ferroptotic mechanisms (Viswanathan et al. 2017), and the FSP1–NADH–CoQ10 axis is one of them, paralleling the GPX4 pathway play a role (Bersuker et al. 2019; Doll et al. 2019). Here, GPX4 is linked to cancer.