Correspondingly, Nrf2, an important regulator of ferroptosis, was found to be attenuated in ALS (Kirby et al. 2005; Wood-Allum et al. 2006), and its reduced activity was shown to be a hallmark of ALS in human biosamples (von Otter et al. 2010; Bergström et al. 2014). The gene discussed is NFE2L2; the disease is amyotrophic lateral sclerosis.