In HT1080 fibrosarcoma cells, HO1 overexpression facilitated ferroptosis brought on by erastin (Kwon et al. 2015; Chang et al. 2018); however, knockdown of HO1 produced the same effect in renal proximal tubular cells and hepatoma cells (Sun et al. 2016; Adedoyin et al. 2018). Here, HMOX1 is linked to hepatocellular carcinoma.