Urate (2,6,8-trioxy-purine), proposed as a prognostic factor for survival in ALS patients due to its reduced levels in the serum of ALS patients (Keizman et al. 2009), is also an important endogenous antioxidant in the body (Sautin and Johnson 2008) that activates Nrf2 by inhibiting GSK3β through Akt (Zhang et al. 2019a). The gene discussed is NFE2L2; the disease is amyotrophic lateral sclerosis.