Urate (2,6,8-trioxy-purine), proposed as a prognostic factor for survival in ALS patients due to its reduced levels in the serum of ALS patients (Keizman et al. 2009), is also an important endogenous antioxidant in the body (Sautin and Johnson 2008) that activates Nrf2 by inhibiting GSK3β through Akt (Zhang et al. 2019a). This evidence concerns the gene GSK3B and amyotrophic lateral sclerosis.