The influence of lipid peroxidation on the Nrf2 pathway is twofold (Dinkova-Kostova et al. 2017): on the one hand, the electrophilic modification of Keap1 by lipid peroxidation products such as 4-HNE can activate the Nrf2 pathway; on the other hand, excessive lipid peroxidation leads to inactivation of Nrf2-regulated antioxidant-related enzymes such as GCL, TXNRD1, and PRDX6 (Dinkova-Kostova et al. 2017), which disrupts the homeostasis of the redox system and drives ferroptosis in AD (Dodson et al. 2019a). The gene discussed is KEAP1; the disease is Alzheimer disease.