In summary, we focus on iron death in a neurological context, the key regulatory role of Nrf2 on iron death, and discuss that the close link between Nrf2 and ferroptosis is of clear and important significance for understanding the mechanism of ND based on OS, characterized by neuronal loss and mitochondrial dysfunction, and represented by AD, PD, HD, and ALS, and point out the bright prospect of Nrf2-targeted therapy in the diagnosis and treatment of ND. This evidence concerns the gene NFE2L2 and Norrie disease.