Although one recombinant form of TRAIL and multiple agonistic anti-TRAIL-R antibodies have advanced to clinical trials, they failed to provide clinical benefit to cancer patients (Forero-Torres et al., 2013; Herbst et al., 2010; Kelley et al., 2001; Merchant et al., 2012; Papadopoulos et al., 2015; Paz-Ares et al., 2013; Soria et al., 2011; von Pawel et al., 2014). Here, TNFSF10 is linked to cancer.