While the exact role of TRAIL-induced internalization in apoptosis remains controversial, and the role could be very different in different tumor cells (Kahraman et al., 2009; Artykov et al., 2021; Mazurek et al., 2012; Zhang et al., 2009), our study in myeloma cells clearly shows that HS promotes rapid internalization of DR5 upon binding with TRAIL. The gene discussed is TNFSF10; the disease is plasma cell myeloma.