In ZDF rats, on the other hand, during phase I with GCG-ZDF-BC and INS-ZDF-BC (Fig. 1, protocol 7), despite sustained hyperglycemia at basal levels, PG and EGP only tended to show a small decrease by 4.3% (−Δ 0.5 mM) and by 2.2% (−Δ 1.3 μmol·kg−1·min−1), respectively, and GC likewise only tended to increase by 5.6% (+Δ1.6 μmol·kg−1·min−1), although these alterations are not statistically significant. The gene discussed is INS; the disease is Hyperglycemia.