INS and Hyperglycemia: In ZDF rats, during phase II when basal hyperglycemia was restored with GCG-ZDF-BC and INS-ZDF-BC, EGP and TGO tended to reduce progressively by 13% (−Δ 7.3 μmol·kg−1·min−1) and 7% (−Δ 6.6 μmol·kg−1·min−1), respectively, with a slight decrease in the EGP fraction contributing to TGO from 66% to 62%.