Even under equivalent hyperglycemia, therefore, both the percentage and absolute rate of decrease of EGP (20% and −Δ 10 μmol·kg−1·min−1, respectively) and increase of GC (33% and Δ 11 μmol·kg−1·min−1, respectively) with GCG-DF compared with GCG-BC in ZDF rats were markedly smaller relative to those in ZCL rats. The gene discussed is GCG; the disease is Hyperglycemia.