Mirroring data in urothelial cells (15), we found that the pro-T cell cytokines CXCL9/10/11 are strongly induced by a combination of IFNγ and EZH2 inhibition in both human and murine tumoroids, and that this gene cluster is a direct PRC2 target in human lung cancer cells. Here, CXCL9 is linked to lung cancer.