Finally, considering that antibodies against IZUMO1 were detected on the sera of infertile women (Clark and Naz, 2013) and here, we observed that a monoclonal antibody against this protein was able to block sperm-induced syncytia, SPICER could serve as a tool to readily analyze cases of immuno-infertility. The gene discussed is IZUMO1; the disease is Infertility.