According to the ratios of observed to randomly expected cell numbers (Ro/e),27 CX3CR1hi CD8+ T cells and Tregs were enriched in SJP and JPS polyps, while CD160hi CD8+ T, TNFhi CD4+ T and GZMAhi NKT cells appeared to be enriched in PJS polyps (Figure 5D). This evidence concerns the gene CD4 and Peutz-Jeghers syndrome.