MYC and Peutz-Jeghers syndrome: Furthermore, gene set enrichment analysis (GSEA) revealed upregulation of the tumorigenesis‐related pathway EMT in early colonocytes and colonocytes in all three polyp subtypes, although the difference was not significant in PJS polyps, while universal downregulation of cell cycle‐related pathways, including MYC targets V1, MYC targets V2, E2F targets and G2M checkpoint, was observed in early colonocytes and/or colonocytes across all three polyp subtypes, especially PJS.