CX3CR1hi CD8+ T cells exhibited higher expression levels of genes associated with cytotoxicity, including GZMA, GZMB, GZMH, PRF1 and NKG7, in SJP and JPS polyps and higher expression levels of IFNG and TNF in PJS polyps (Figure 5G). The gene discussed is TNF; the disease is Peutz-Jeghers syndrome.