The binding of TNF‐α to its receptors (TNFR1 and TNFR2, coded by TNFRSF1A and TNFRSF1B, respectively) effectively stimulates apoptosis and necrotic cell death, which can lead to inappropriate acute and chronic inflammatory processes, resulting in severe pathologies, such as inflammatory bowel disease.36 This evidence concerns the gene TNFRSF1A and inflammatory bowel disease.