TGFB1 and Peutz-Jeghers syndrome: Interestingly, compared with normal tissue, SJP and JPS polyps showed upregulation of the pathways involved in EMT signalling, including hypoxia, TGF‐β, MAPK and WNT, in the C6 subset, while only hypoxia and TGF‐β were upregulated in PJS polyps (Figure 6F).