Similarly, an enhanced proinflammatory response by fibroblasts was also found, and these activated fibroblasts promoted the migration of T/ILCs as well as myeloid cells to polyp tissues by secreting chemokines, such as CXCL2, CXCL3 and CXCL8 and interacting with most other cell subsets through the collagen signalling network in SJP and JPS polyps but not PJS polyps. The gene discussed is CXCL8; the disease is juvenile polyposis syndrome.