In addition, SJP and JPS polyps exhibited the majority of DEGs in most subsets except for TNFhi CD4+ T cells, MAIT cells and ILC3s, whereas PJS polyps showed the majority of DEGs in GZMAhi NKT cells, suggesting that immune cells have wide functional changes in polyps, especially SJP and JPS polyps (Figure 5E). Here, CD4 is linked to Peutz-Jeghers syndrome.