LGR5 and juvenile polyposis syndrome: In addition, the VEGF signalling network acting on endothelial cells was increased in SJP and JPS polyps, reflecting that monocytes, pDCs and epithelial subsets, including LGR5+ stem cells, tuft cells and TA cells, were the main cell subsets interacting with endothelial cells in normal tissue, while mast cells and/or monocytes were the main cell subsets in polyps, which agreed with the increased activity of endothelial cell adhesion in SJP and JPS polyps (Figure 7E).