Next, we focused on the core DEGs in the gene set of the TNF‐α response via NF‐κB in all cell subsets from each polyp subtype and found that 11, 13 and 3 upregulated DEGs were shared by these cell subsets with a remarkable response to TNF‐α in SJP, JPS and PJS polyps, respectively (Figure 3B). This evidence concerns the gene TNF and Peutz-Jeghers syndrome.