Compared with SJP or PJS polyps, endothelial cells in JPS polyps exhibited increased levels of DEPP1, EDN1, CCN1, SELE or ACKR1, which are involved in the regulation of oxidative stress, vascular contraction, cell adhesion or leukocyte chemotaxis. This evidence concerns the gene ACKR1 and Peutz-Jeghers syndrome.