also demonstrated that SPON2 exerts inhibitory effects on the migration, invasion, and metastasis of CRC cells by impeding the interaction between WNT5a and Fzd7 receptor, thereby antagonizing the non-classical WNT pathway mediated by WNT5a/FZD7 in advanced CRC (58). The gene discussed is WNT5A; the disease is colorectal carcinoma.