conducted a tissue microarray immunohistochemical analysis (TMA-IHC) to examine the expression of SPON2 protein in 280 lung cancer patients, revealing that elevated levels of SPON2 protein were significantly associated with differentiation, positive lymph node metastasis, increased serum carcinoembryonic antigen levels, and poor overall survival. The gene discussed is SPON2; the disease is lung carcinoma.