GATA3 and acute lymphoblastic leukemia: For several of the ALL-associated SNPs, including in ARID5B, GATA3, and PIP4K2A (70–73), the risk allele frequencies have been reported to be higher in Hispanic/Latino populations than in Europeans in reference population databases such as the Genome Aggregation Database (gnomAD) (Table 1), supporting a role for genetic variation in the higher incidence of ALL in Hispanics/Latinos.