CRLF2 and acute lymphoblastic leukemia: One such factor may be childhood obesity, which has increased in incidence in the United States in recent years (103), has a higher prevalence among Hispanic/Latino children (104, 105), and has been associated with an increased risk of ALL in Hispanics/Latinos (106) and with an increased frequency of somatic CRLF2 rearrangements among Hispanic/Latino ALL patients (107).