Although it has been previously believed that surgical treatment can reduce tumor load and decrease the risk of tumor metastasis, thereby improving patient prognosis, particularly in patients with bone metastases only or oligometastases, Possible mechanisms for this effect include increasing the number of CD4 and CD8 T-cells to enhance the anti-tumor immune response, as well as removing some tumor stem cells to reduce the risk of metastasis (5, 23). This evidence concerns the gene CD4 and neoplasm.