In recent years, tumour immunotherapy mediated by nanomaterials has attracted much attention.[21, 22] Herein, we constructed tumour intracellular microenvironment responsive ZnFe2O4 nanoparticles loading low‐dose paclitaxel (PTX) (ZnFe2O4‐PTX) to programmatically initiate cGAS/STING pathway (Figure 1A). Here, STING1 is linked to neoplasm.