In brief, after cGAS senses the cytosolic DNA in tumour cells, STING is activated to mediate type I interferon production and proinflammatory cytokine secretion, thus inducing innate immune responses and bridging to adaptive immunity.[1, 2] However, double stranded DNA (dsDNA) is normally absent in the cytoplasm,[3] which limits the cGAS/STING pathway activation.[4] Therefore, triggering the exposure of DNA to the cytosolic DNA sensor (cGAS) play a pivotal role in priming cGAS/STING signalling pathway. The gene discussed is STING1; the disease is neoplasm.