For instance, PO43− is reported to restore the activity of adenosine kinase (ADK), which reduces the accumulation of adenosine (Ado) in tumor tissue and relieve the Ado‐mediated immunosuppression, resulting in enhanced antitumor immune response.[30] High concentration of CO32− in aqueous medium will release CO2 bubble, which have been widely used in ultrasonic therapy and ultrasonic imaging.[31] Hence, it is necessary to review the recent advance of CaP‐mineralized GOx and CaCO3‐mineralized GOx in cancer therapy to stimulate more interest on them. This evidence concerns the gene ADK and cancer.