INS and obesity due to melanocortin 4 receptor deficiency: T2DM is an insulin‐dependent disease featured with abnormal glucose metabolism, which is influenced by many factors including age, obesity, sedentary behavior, dietary changes etc. INS administration is the primary treatment of diabetes, and glucose responsive GOx‐based carrier can mimic the dynamic biological process of insulin secretion by β‐cells to maintain the stability of blood glucose, is promising for personalized treatment.[55] For instance, Jiang et al.