We found genetically predicted CD33dim HLA DR+ CD11b- %CD33dim HLA DR+ myeloid cell (OR: 1.09, 95% CI: 1.05–1.14, P=1.68 × 10−5), HLA DR+ CD4+ T cell %T cell (OR: 1.16, 95% CI: 1.08–1.25, P=4.40 × 10−5), HLA DR+ CD4+ T cell % lymphocyte (OR: 1.17, 95% CI: 1.09–1.27, P=5.05 × 10−5) and CD27 on switched memory B cell (OR: 1.10, 95% CI: 1.05–1.16, P=1.51 × 10−4) may be associated with the development of CD (Table 3; Figure 3). The gene discussed is CD27; the disease is Cowden disease.