In the IBDGC cohort, we found genetically predicted CD27 on IgD+ CD24+ B cell (OR: 1.09, 95% CI: 1.04-1.14, P=1.76× 10-4), CD27 on CD24+ CD27+ B cell (OR: 1.13, 95% CI: 1.06–1.21, P=3.18× 10-4), CD27 on switched memory B cell (OR: 1.11, 95% CI: 1.05–1.18, P=3.62× 10-4) and CD33dim HLA DR+ CD11b- %CD33dim HLA DR+ myeloid cell (OR: 1.15, 95% CI: 1.08–1.22, P=1.17× 10−5) can increase the risk of IBD (Table 2; Figure 2). Here, CD27 is linked to inflammatory bowel disease.