CXCL12 and cancer: In addition, genes involved in leukocyte recruitment (Cxcr2) or promotion of metastasis (Ccr5) had higher expression after cancer cell implantation while genes that regulate B cell migration and chemotaxis (Cxcl12, Cxcl13) were downregulated; this correlates with the reduction of the B cell marker Cd19 and confirms the reduction of B cells in the PSF in the HFD and the cancer group (Supplementary Table S2A).