Key cytokines and chemokines and their receptors in addition to growth regulators (Areg, Csf1, Gdf6, Nrg1, Pdgfa, Spp1), adhesion (F11r, Fn1) and stemness modulators (Hdac7, Lefty1, Procr), and genes associated with progressive disease (Apoa2, Apol7a, Inhba, Mif, Nos2, Olr1, Prl, Tnfsf9, S100a8) were upregulated in the OFB with the cancer cells. This evidence concerns the gene SPP1 and cancer.