The combination of HFD and MOSE-LTICv led to an exacerbation of the expression of the pro-inflammatory cyto/chemokines (Ccl2, Ccl3, Ccl4, Cxcl13, Ifng, Il1b, Il10) over the LFD/MOSE-LTICv group; other genes were not further affected by this combination beyond the impact of the HFD or the cancer cells alone. The gene discussed is CCL4; the disease is cancer.