CXCL3 and cancer: As shown in Figure 8, both the HFD and the cancer cells increased the expression of most genes; however, especially Il1b, Ym1, Cxcl2, Cxcl3, and Cxcr2 were among the most responsive genes to both the HFD and the cancer cells in the PSF which were further exacerbated by the combination of the HFD and cancer cells.