SPP1 and cancer: In addition, the expression of regulators of growth (Nos2, Spp1) and metabolism (Ins1, Tymp), as well as indicators of cancer progression (Cer1, Fos, Saa4) were exacerbated while genes such as Adora1, Ccl6 that are often low expressed in cancer and genes that inhibit cancer growth and development (Gdf1, Grem2, F2, Kng1, Ltb4r1, Nodal) were further down-regulated compared to the LFD MOSE-LTICv group (Supplementary Tables S1, S3).