TNC and cancer: The HFD alone increased genes encoding matrix proteins such as COL1 and TNC in the OFB and exacerbated cancer-mediated increases in Col1, Tnc, and Fn1. These proteins have shown to increase adhesion, invasion, proliferation, and migration of ovarian metastases (65–68); FN1 has been also shown to be important marker for the transformation of the ovarian epithelial cells to a mesenchymal phenotype and the formation of aggregates (69, 70) while COL1 increased resistance to paclitaxel (71) and cisplatin (72) treatment.