The combination of HFD plus cancer resulted in increased expression of some cytokines in the OFB (e.g., Ccl2, Ccl4, Cxcr2, Il1b) and decreased expression of others (e.g., Ccr5, Cx3cl1, eNos, Tnfa) as compared to the HFD group alone (Table 2). The gene discussed is IL1B; the disease is cancer.