TT higher susceptibility to TBM (OR 1.24, 95% CI 1.03-1.49) but not PTB; higher mortality in TT & TC in a Vietnamese discovery, and Vietnamese and Indonesian validation cohorts; lower CSF TNF and IFNγ concentrations in T allele. n=407 TBM (susceptibility cohort), n=210 TBM (Vietnam discovery), n=87 TBM (Vietnam validation), n=468 TBM (Indonesia validation). This evidence concerns the gene IFNG and meningeal tuberculosis.