MPO and meningeal tuberculosis: In a study looking for a CSF biosignature for TBM using proteomics in HIV-uninfected children, a combination of VEGF-A, IFNγ and myeloperoxidase had a sensitivity and specificity of 91.3% and 100% respectively compared to a heterogeneous non-TBM group, suggesting VEGF-A as an important contributor in TBM pathogenesis (41).