Other polymorphisms have been associated with developing TBM include those encoding for mannose-binding lectin (MBL2), TLR2, TLR9, toll-like adaptor protein (TIRAP), toll-like receptor/IL-1R signalling (PKP3-SIGIRR-TMEM16J gene region), vitamin D receptor (VDR) and the lung protein mucin-5AC (MUC5AC) (108, 109, 111–116). Here, MUC5AC is linked to meningeal tuberculosis.