FOS and osteoarthritis: Increasingly, the role of glycolysis for OA chondrocyte function is also being focused on, for example, it was recently shown that the activator protein 1 (AP-1) transcription factor component, c-Fos, regulates chondrocyte cellular bioenergetics by balancing pyruvate fluxes between anaerobic glycolysis and the tricarboxylic acid cycle in response to OA signaling, controlling chondrogenic integrity in osteoarthritis (26).