In general, CXCR3 is highly expressed on the surface of NK cells, and it drives NK cell-specific chemotaxis toward the CXCR3 ligands CXCL9, CXCL10 and CXCL11, which are secreted by tumor cells into TME and usually expressed at relative low levels in homeostatic condition (50–52). This evidence concerns the gene CXCL9 and neoplasm.