In addition, several evidences reveal that CXCR3 on tumor cells surface facilitates the proliferation and metastasis of a variety of malignancies, including colon cancer (60) and melanoma (61), and CXCR3 blockade has shown a prospective anti-metastatic potential in breast cancer (62). The gene discussed is CXCR3; the disease is malignant colon neoplasm.