Here, hUCB-MDSCs (1 × 105 and/or 1 × 106 cells) restored skin barrier function and improved skin fibrosis, suggesting that the anti-inflammatory effects and wound-healing capacities of hUCB-MDSC therapy are the mechanisms responsible for recovery from skin barrier impairment and dysfunction and skin fibrosis in Df-induced AD-NC/Nga mice. The gene discussed is CFD; the disease is Alzheimer disease.