Figures 2E–G shows fewer F4/80, CD206, and Arg-1 positive tumor-infiltrating macrophages were observed in Mvp-/- mice compared with Wt mice. Similarly, Flow cytometry (FC) further revealed that the number of F4/80+ CD11b+ CD206+ macrophages was reduced in tumor tissues of Mvp-/- mice compared with Wt mice (Supplementary Figures 3A, B). Thus, these data collectively suggest that MVP deficiency inhibited HCC tumor growth in vivo, which may be associated with a reduction in M2-like TAMs infiltration. This evidence concerns the gene ARG1 and hepatocellular carcinoma.