The AgNPs synthesized from L. coccineus and M. lutea exhibited high anti-acetylcholinesterase activity at 0.82 ng/mL and 1.36 ng/mL respectively while the anti-acetylcholinesterase activity of synthesized AgNPs was comparable to rivastigmine, which is a standard drug used for the treatment of neurodegenerative diseases. This evidence concerns the gene ACHE and neurodegenerative disease.