RHOA and Familial prostate cancer: Iglesias-Gato et al. (2015) screened for the effects of OTU-family DUBs on prostate cancer cell proliferation, migration, and invasion with the siRNA library. They found that OTUB1 promotes the invasion and tumorigenesis of prostate cancer in vitro and in vivo by promoting Rho-A activation. In addition, Liao et al. (2020) also found OTUB1 promotes the progression and proliferation of prostate cancer cells.