Meanwhile, considering the crucial role of EZH2 in cancer carcinogenesis and development through PRC2, numerous molecules have been synthesized and developed as potent EZH2 inhibitors, including DZNep, GSK126, tazemetostat, and CPI-169 (Bitler et al., 2015; Jiang et al., 2021). Here, EZH2 is linked to cancer.