Additionally, Gal-9 interacts with macrophages in patients with metastatic melanoma, causing CD206+ macrophages to produce increased levels of FGF2 and monocyte chemotactic protein-1 (MCP-1) while reducing macrophage-derived chemokines (MDC) (Enninga et al., 2018). The gene discussed is CCL22; the disease is metastatic melanoma.