SIRT3 and osteoporosis: Regarding bone formation, SIRT3 has been demonstrated to mitigate mitochondrial oxidative stress and mtDNA damage in vitro in osteoblasts In 2017, sirt3 knockout mice exhibited the onset of osteoporosis at 8 weeks of age (92), while the overexpression of sirt3 via intravenous injection of recombinant adeno-associated viruses carrying sirt3 plasmids significantly ameliorated osteoporosis in SAMP6 mice in 2020.