Huang et al. generated mice with Arf6 deficiency in platelets, they found that hemostasis phenotypes (e.g., aggregation, ADP secretion, tail bleeding times, and occlusion time of arterial thrombosis) were normal, yet, Arf6 deficient platelets displayed enhanced spreading on fibrinogen and accelerated clot retraction. Here, ARF6 is linked to Arterial thrombosis.