Recent studies have also highlighted HEFPs can also activate the extrinsic apoptotic pathway (TRAIL, Fas-L) and downregulate the expression of Bcl-2 and Bcl-XL in AGS cells (human gastric adenocarcinoma cells) while stimulating the histone H3K4me3 binding of FasL and TRAIL. The gene discussed is FASLG; the disease is gastric adenocarcinoma.