Some of these pathways are known to be more commonly mutated in breast cancer, for example, the mitogen-activated protein kinase (MAPK) pathway, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway, Wnt/β-catenin pathway and Janus kinase (JAK) and signal transducers and activators of transcription (STAT) pathway[61]. This evidence concerns the gene AKT1 and breast carcinoma.