When CLL and MCL cells were preincubated with anti-apoptotic/pro-growth signaling factors from outside the direct BCL2 pathway, namely sCD40L, IL-10, CpG-ODN, B-cell-activating factor (BAFF), CXCL3, the combination of sCD40L, IL-10, and CpG-ODN had the lowest level of ibrutinib/venetoclax induced cytotoxicity indicating resistance[31]. This evidence concerns the gene TNFSF13B and B-cell chronic lymphocytic leukemia.