PTEN and prostate cancer: Some lymphomas are auxotrophic for cholesterol because of hypermethylation and silencing or mutation of de novo cholesterol biosynthesis genes.[40] Accumulation of cholesteryl esters has also been reported in PTEN‐null prostate cancer being associated with increased aggressiveness,[13] and dependence on cholesterol uptake through SR‐B1 was described in clear cell renal cell carcinoma.[35] The latter is notoriously resistant to chemotherapy and auxotrophic for cholesterol from exogenous sources.