Cellular cholesterol uptake is mediated by cholesterol‐rich HDL and LDL[18] and both lipoproteins types have been implicated in cancer.[19] LDLs target the LDL receptor (LDLR) for holoparticle internalization via clathrin mediated endocytosis.[20] Cholesterol from the degraded LDL particle is ultimately re‐esterified and stored in cytoplasmic lipid droplets (LDs) or transferred to the cell or mitochondrial membranes via the ER. This evidence concerns the gene LDLR and cancer.